Thursday, July 11, 2013

Concealed Carry To Mean Big Business In QCA - News and ...

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Gun businesses say sales and demand for classes and training are already booming as Illinois residents begin getting their concealed carry permits.

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Taking 16 hours of training to get it, they expect business to just keep going up.

Business owner Tim Baldwin said he and many others have been waiting for Illinois to get a concealed carry law for years.

"We're excited it's finally gotten done, and although not perfect, I think it's pretty good," said Baldwin, co-owner of Shooting Sports in Moline. ? ??

Baldwin took over Shooting Sports in Moline with his partner last year, just in time for Illinois to get the law and give them a big business boost.?

"Certainly it's going to increase business," said Baldwin. "We'll be busier with our training facility, our range will be busier, not only with our instructors and students but other instructors and students."

Baldwin said depending on just how much business takes off, they may expand their range and hire more instructors. And it's not just his business but others offering training that expect to profit too.

"Hopefully it'll be a boost for them and a boost for the economy," said Darin Oberhart, owner of QCI Firearms Training. "Gun sales have been at astronomical levels. Hopefully it will just continue that trend."

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Oberhart teaches gun safety courses and his phone has been ringing off the hook with interest. Even businesses that don't offer classes expect to rake in the cash too.

"There will be a boost in business yes, because now people are going to have to come over and get concealed guns" said Randy Fulton, owner of R&K Arms. "Before it was all planking guns, bigger frame guns, that kind of stuff, now you have to come back to concealed carry guns."

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While concealed carry permits and classes aren't available just yet businesses say it's just a matter of time.?

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Source: http://www.kwqc.com/story/22809968/concealed-carry-to-mean-big-business-in-qca

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Court upholds Nevada's unique "none" ballot option

CARSON CITY, Nev. (AP) ? "None of the above," Nevada's perpetual ballot loser, got a legal victory Wednesday and will continue to be an option for voters after a federal appeals court rejected a Republican-backed lawsuit challenging its constitutionality.

A three-judge panel of the 9th U.S. Circuit Court of Appeals dismissed the suit, ruling that the 11 plaintiffs lacked standing.

Nevada is the only state in the nation that that gives voters the option of "none of these candidates" in statewide races ? president, U.S. Senate, state constitutional offices and the Nevada Supreme Court.

But under state law "none" can never win even if it receives the most votes, though it can play spoiler.

Republicans sued last year over the law, fearing "none" could siphon votes from a disgruntled electorate and sway the outcome of a close 2012 presidential and Nevada U.S. Senate race.

The suit argued "none" disenfranchises voters because it has no legal bearing on an election. In legal briefs, attorney Paul Swen Prior argued that votes for "none" are treated as "legal nullities" under the law, while voters who choose "none" are disenfranchised because their choice has no legal standing on the outcome.

Secretary of State Ross Miller, Nevada's chief election officer, however, hailed the ruling as "a triumph for Nevada voters."

"Voters who want to express their dissatisfaction with the federal and statewide candidates on the ballot should have the option and freedom to do it," Miller said.

The suit argued that to be constitutional, Nevada's election law should give more legal weight to "none" by allowing it to win and setting up a process for voters to then decide on another living candidate, such as declaring a vacancy or having a follow-up election.

But the appellate judges, while making no determination on the merits of those arguments, said the plaintiffs' positions "are questionable."

The "none" option has been on the ballot in Nevada since 1976. It was enacted by the Legislature the previous year as a way to combat voter apathy in the wake of the Watergate scandal that brought down President Richard Nixon. The intent was to give voters a way to voice their displeasure with candidates and elected officials at the ballot box.

"None" has never received the most votes in a general election but is often a popular choice that can and has played spoiler in high-profile races.

It wasn't a factor in last year's hard-fought president contest between President Barack Obama and GOP nominee Mitt Romney. But it played a familiar role in Nevada's U.S. Senate race between Republican Sen. Dean Heller and Democratic challenger Shelley Berkley, a seven-term congresswoman.

Heller defeated Berkley by about 12,000 votes. More than 45,000 votes were cast for "none."

In 1998, U.S. Sen. Harry Reid defeated then Republican Rep. John Ensign by 428 votes, but more than 8,000 voters rejected both men and opted for "none."

Source: http://news.yahoo.com/court-upholds-nevadas-unique-none-ballot-option-234606655.html

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Wednesday, July 10, 2013

iPhone, Android apps from PDFs?

Looking to create standalone apps for iPhone, Android phones, and Android tablets that will present a digital replica of a booklet based on PDFs from the printed version.

I have access to Adobe DPS but I understand it only produces standalone (aka "single folio") apps for the iPad -- so I'm covered there, but need to do the same thing for those other platforms. I prefer a Mac tool but could use a PC one if necessary; this looks like it would work (for Android at least) but it doesn't cover iPhone. Thank you! posted by rleamon to computers & internet (2 answers total)

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Source: http://ask.metafilter.com/244369/iPhone-Android-apps-from-PDFs

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Tuesday, July 9, 2013

Business Networking With Dr. Ivan Misner ? Business Networking ...




Last week I posted a blog explaining why I believe that understanding the buyer?s perspective is one of the most important keys to selling.? Today?s post is a follow up to that post because I want to take this opportunity to offer some tactics for tapping into the buyer?s (i.e., the customer?s) p...


I?ve done quite a few video blogs with Tiffanie Kellog and there?s a very good reason for that . . . she is an outstanding Referral Institute? Trainer, Consultant, & Speaker and she has an unending supply of highly useful ideas and comments to offer. In this video, I talk with Tiffanie about the power of...


A few weeks ago, I was sitting in an airport waiting for my plane to arrive and I struck up a conversation with the young man sitting next to me.? He was wearing a nice suit, carrying a laptop, and appeared to be traveling on business so I asked him if he happened to be traveling to the same business event that I was.?...


When you?re at a busy networking event, sometimes it?s easy to fall into the trap of not giving people your undivided attention.? However, making every effort to avoid that trap and to, instead, be fully present and focused on each conversation you have will no doubt help you make a huge impression on people...


We?ve all heard the phrase ?It?s not so much about what you say, it?s more how you say it that really matters? and, let me tell you, I learned the hard way how true that actually is.? Conversations can be tricky?especially when one or more of the people involved are upset. Back in the...


Ugh . . . jet lag?the dreaded tormenter of travelers far and wide.? I know a thing or two about traveling as it?s a huge part of my career and my years of consistent traveling have taught me the one and only thing I need to know about jet lag which I?m going to share with you today.? Last year alone, ...


If you believe that promoting yourself, in the traditional sense, is the best way to get referrals, I hate to break it to you but it?s actually not a particularly effective way of generating referrals.? The thing is, just talking about yourself is not enough?you?ve got to teach people how to refer you....


In this fourth and final installment of the ?Why People Resist Networking? Video Series, I discuss a fourth reason why people likely shy away from networking?Lack of Understanding. Unfortunately, many people simply don?t understand what networking is and, in addition, they don?t understand t...


No matter what we call it, we all pursue success.? We all have desires and strive to achieve them.? Our desires may be different from anyone else?s, and we may not consider achieving them to be ?success.?? We look around and see people whose success we envy.? What is Jake doing with his supply of ho...


In this third installment of the ?Why People Resist Networking? Video Series, I discuss another popular theme surrounding why people tend to resist networking ? impatience.? If new networkers don?t see immediate payoff from their efforts, they become impatient, inevitably resulting in failure early on in the...


Peter Drucker once said, ?The most important thing in communication is to hear what isn?t being said.? ?This is so true and extremely important because the quality of our relationships depends on the quality of our communications; and when it comes to sales for your business and growing your business t...


In this second installment of the ?Why People Resist Networking? Video Series, I discuss another commonly held idea behind why people most likely resist networking?they claim they are much too busy to network. The bottom line is that though people may feel they ?don?t have the time? or...


Over the past few weeks, I?ve posted blogs on how embracing quality, adding members, and seeking engagement are all things that will help networkers and entire networking groups achieve success.? Today, I?d like to talk about an additional tactic for obtaining stellar networking results?sharing stories...


? In this first video in the ?Why People Resist Networking Series,? I list four ideas about why people most likely resist networking and then delve more deeply into detail about the very first idea?Lack of Confidence. I offer insight into three different reasons why people lack confidence when it c...


View All Posts

Source: http://businessnetworking.com/

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Symmetry Corp. leases third Milwaukee building, adding 15 jobs

File photo

Symmetry Corp. president Dan Wilhelms said his IT firm is committed to expanding in Milwaukee.

Symmetry Corp. has moved into its third location on Milwaukee?s east side and plans to add 15 jobs locally by the end of the year, the company said Tuesday.

Symmetry, the Milwaukee-based information technology firm, is leasing the building at 1443 N. Prospect Ave. It will use the 7,638 square feet of office space to provide employee training and customer service.

Symmetry will grow its Milwaukee employee base from 75 to 100 by next year. It now has a total staff of 85 at its three Milwaukee locations and satellite offices nationwide, said president Dan Wilhelms.

The company has enjoyed three consecutive years of significant growth. It added 30 jobs last year, Wilhelms said.

?We?re committed to Milwaukee and the east side,? Wilhelms said in a phone interview. ?Hopefully economic factors will allow us to continue to grow in Milwaukee.?

Symmetry?s third facility was built in 1968. The other two company locations are on the National Register of Historic Places: the 19th century Judge Jason Downer house on the lower east side, 1201 N. Prospect Ave., and the Adler Building, 1681 N. Prospect Ave.

Jeff Engel is The Business Journal's reporter covering the manufacturing industry and technology.

Source: http://feedproxy.google.com/~r/vertical_43/~3/fSYIR6bC3lg/symmetry-corp-leases-third-milwaukee.html

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Monday, July 8, 2013

PCH CEO Liam Casey appointed to Action Plan for Jobs 2013 Group by Irish Government

The Group will help implement seven "Disruptive Reforms" to create more jobs in Ireland

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PCH International Founder and CEO Liam Casey has been appointed by the Irish Government as one of six leading businesspeople to join the Action Plan for Jobs Implementation and Monitoring Group, which will help to implement seven "disruptive reforms" planned for 2013. The aim of the group is to assist in making Ireland more attractive and competitive for jobs and investment.

Liam commented: "I am delighted to be involved in this important initiative - anything "disruptive" appeals to me! We are at a critical time in global commerce where geography is history. We need to identify and go after global opportunities. Irish businesses are world leaders in many fields. Over the past 30 years we have developed great skills in many areas, in particular in technology and pharmaceuticals - we need to continue this.

"We should attract more foreign companies into Ireland and we need to encourage Irish entrepreneurs to build more companies like Kerry Group, CRH, Glen Dimplex, Kentz, Dairymaster, Digicel, Ryanair, Smurfit Kappa etc. There are opportunities in food production, agriculture, ICT and energy efficiency. Through the Disruptive Reforms, government and business people can work together to nurture these skills and ensure that Irish people and Irish companies continue to make a huge impact around the world and create jobs in Ireland."

The Seven Disruptive Reforms include:

1. JobsPlus - over two years the State will pay ???1 of every ???4 it costs an employer to recruit a long-term unemployed person off the Live Register

2. ICT Skills - provide an additional 2,000 ICT graduate level professionals in 2013, and by 2018 lead Europe in terms of ICT graduates as a percentage of all third level graduates

3. Energy Efficiency - the Government will create a ???70million Energy Efficiency Fund to support 20 major projects in 2013 and ultimately create 5,000 jobs

4. Trading Online - get 2,000 more small businesses trading online in 2013 and 2014, with the creation of 3,200 jobs

5. Business Licences - create a single licensing application system for up to 25 licences in the retail sector, saving retailers over ???20million per annum

6. Big Data - make Ireland one of the leading countries in Europe for Big Data, a sector growing by up to 40% per annum

7. Health Innovation Hub - Government will establish a world-renowned centre to establish Ireland as a leading location for start-up and growing medtech and healthcare companies

More information can be found about the initiative here

About PCH International

PCH International creates, develops, and delivers the world's best products for the world's best brands. We offer transparent, sustainable product development and supply chain management services to a diverse range of clients, from Fortune 500s to innovative startups. Headquartered in Ireland since 1996, with operations in China, we believe geography is history. Our 5000 team members from 16 nationalities share the same purpose: Developing Partnerships Delivering Peace of Mind. www.pchintl.com

Media Contact: pr@pchintl.com

Source: http://www.pchintl.com/Newsroom/action-plan-for-jobs-2013.aspx

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Founder of Blackwater security co. writing memoir

NEW YORK (AP) ? The founder of the private security firm Blackwater Inc. is writing a memoir.

Erik Prince has a deal with Portfolio, an imprint of Penguin Random House. The publisher announced Monday that the book, currently untitled, is scheduled for November.

Prince, a former Navy SEAL who has rarely spoken to the media, said in a statement released by Portfolio that he was anxious to counter Blackwater's controversial image.

"Hundreds of American citizens employed by private military contractors, or PMCs, would lose their lives helping our government wage wars in Afghanistan and Iraq, only to have their memory tarnished by the unfair and/or ignorant depiction of PMCs as profiteers, 'jackbooted thugs,' or worse by the media and the political establishment that asked for our help in the first place," Prince said. "It's partly to honor their memory that I've written this book."

Blackwater was founded in North Carolina in 1997 by Prince, whose book will also challenge numerous reports that his company was awarded no-bid security contracts from the U.S. government at the beginning of the Iraq War. Blackwater became the focus of international scrutiny and ongoing legal action when guards were involved in a series of high-profile shootings.

A group of investors bought Blackwater from Prince in 2010 and renamed it.

Source: http://news.yahoo.com/founder-blackwater-security-co-writing-memoir-203030593.html

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Potentially hundreds of women wrongly sterilized in California prisons

By Stephen C. Webster
Sunday, July 7, 2013 21:48 EDT

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The California Department of Corrections and Rehabilitation wrongly sterilized nearly 150 women between 2006 and 2010, The Center for Investigative Reporting (CIR) has learned.

CIR reporter Corey G. Johnson obtained a database of contracted medical procedures that showed 148 women who were confirmed to have been given tubal ligations, but the report noted that there may be another 100 or more dating back to the 1990s.

Advocates for female prisoners in the state told Johnson that most of the sterilizations were coerced and inmates thought most likely to be jailed again were targeted.

Christina Cordero, who spent two years in Valley State Prison and was sterilized during her time there, reportedly said that the facility?s OB-GYN doctor began suggesting the procedure ?as soon as he found out that I had five kids.?

Another inmate who landed in the prison while pregnant with her eighth child reportedly said she was sterilized and never told why. ?I figured that?s just what happens in prison ? that that?s the best kind of doctor you?re going to get,? the report quotes 42-year-old Nikki Montano as saying.

Johnson also discovered that the procedures were carried with no official sanctions, in spite of a state law that requires individual approval by state medical officials.

The state formally banned the widespread practice of sterilizing repeat offenders and the mentally handicapped in 1979.
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["Stock Photo: Upset Businesswoman Standing Behind Bars In Jail" on Shutterstock.]

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Source: http://feedproxy.google.com/~r/TheRawStory/~3/Z-Inh2ps26M/

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Sunday, July 7, 2013

Canadian town rocked by explosions after oil train derails

Source: http://www.standard.co.uk/news/world/canadian-town-rocked-by-explosions-after-oil-train-derails-8692472.html

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Via MLB?s official Twitter, here are the starting position players for the 2013 All-Star Game at Citi Field:

Nothing too shocking on the National League side of things. In a more Sabermetrically-inclined universe, Matt Carpenter could have gotten the nod over Brandon Phillips. If Troy Tulowitzki isn?t healthy enough to return, you?ll see either Jean Segura or Everth Cabrera at shortstop. ?CarGo? refers to Rockies outfielder Carlos Gonzalez, not Carlos Gomez of the Brewers. Gomez probably should have gotten the nod over Bryce Harper given the playing time disparity. (By the way, Harper?s 201 PA total is closer to that of Yasiel Puig ? 127 ? than Gomez?s 325.)

In the American League, one could make a solid numbers-based case for Jason Kipnis over both Robinson Cano and Dustin Pedroia. Jhonny Peralta has been markedly better than J.J. Hardy but has half the home run total. Adam Jones could have been a reserve in favor of someone like Brett Gardner or Jacoby Ellsbury.

The pitchers:

Shocking not to see Stephen Strasburg, 4-6 but with a 2.24 ERA, not make it. Adam Wainwright won?t pitch in the All-Star Game, so it seems pretty open-and-shut that Matt Harvey gets the nod to start the game in his team?s stadium. With Jason Kipnis on the roster, the ?one player from each team? rule was satisfied, making it odd that Justin Masterson earned a spot while Royals hurler Ervin Santana was left off. But other than that, there aren?t any huge omissions as far as AL pitchers go. And the reserves:

Allen Craig getting the last first base roster spot for the NL over Freddie Freeman is sure to cause some debate. In a surprisingly stacked year at the position, Ian Desmond has been the fourth-best shortstop in the NL, which may explain why he didn?t make the cut. Where is Reds center fielder Shin-Soo Choo and his .417 on-base percentage?

Josh Donaldson is the biggest AL omission that jumps out at you. The Athletics third baseman has a .903 OPS, fourth-best among all MLB third basemen and third-best in the American League behind Miguel Cabrera and Evan Longoria. Longoria, by the way, also not an All-Star.

The Final Vote candidates:

We may see Yasiel Puig in the All-Star Game, after all. The Cuban, setting the baseball world on fire, has a 1.155 OPS through his first 30 Major League games. All five of the AL candidates are pitchers, and relievers at that. Would that we could submit two Final Votes for NL players and zero for the AL in this case.

Source: http://hardballtalk.nbcsports.com/2013/07/06/the-all-star-game-rosters-have-been-unveiled/related/

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wimbledon tennis Streaming Grand Slam tournament : Cool!!Watch Third Grand Slam Tennis 2013 Wimbledon 127th Championships at the All England Lawn Tennis and Croquet Club in Wimbledon, London, United Kingdom, 24 June to 7 July 2013

Most Exciting Grand Slam Tennis 2013 Wimbledon Championships starts at the All England Lawn Tennis and Croquet Club in Wimbledon, London, United Kingdom, from 24 June to 7 July 2013. This will be the 127th championships, and the third Grand Slam tournament of 2013 played on grass courts. They were organized by the All England Lawn Tennis Club and the International Tennis Federation. The defending champions in the Men?s and Women?s singles are Roger Federer and Serena Williams. So Don?t miss to watch 2013 Wimbledon live Streaming Free, TV Schedule, Live Score, Highlights Video on 24th June to 7th July.

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When: 24 June ? 7 July 2013
Where: England Tennis Club, Wimbledon, London UK
Court Surface: Grass
Total Purse: Over $23 million
Category: Grand Slam tournament?

Click To Watch Grand Slam Tennis 2013 Wimbledon Championships Live streaming

Day 1 ? First Round :: Tennis Grand Slams 2013 ? The Championships Wimbledon 2013 :: London, England

Be aware that not all channels will have the tennis all day long, there could be interruptions. For the Order of Play see the Wimbledon Website | You can also check the Wiziwig Forum where you can discuss and chat about this event, find the order of play and all other info! | Have fun watching!!!

At tennis Grand Slams, the brackets are based on a mix of luck as well as past accomplishments. The No. 1 seed cannot face the No. 2 seed until the finals, although the rest of the bracket is pretty much up for grabs.

On the Friday before the tournament begins, the defending champions will pick the seeded players at random for the spots they will be placed in the draw. Roger Federer will select the women?s bracket, and Serena Williams will select the men?s draw to make sure there is no doubt over fairness.

By the end of the day, everyone will know his or her path to the finals, although not everyone will be happy about it.

Men?s Singles

The men?s draw is set to get interesting in a hurry. While the French Open had only a couple of players reasonably capable of winning it all, this year?s Wimbledon championship is incredibly deep.

Djokovic comes in as the top seed after a dominant year of play. He is the most consistent player in the world at this point, and he won this event two years ago.

On the other hand, Federer is the defending champ and continues to show that he is the best in the sport on grass. The seven-time winner also recently won at Halle, so he will come in with some momentum for the first time all year.

Of course, Nadal is the hottest player on tour after an impressive clay-court season. He is 43-2 in 2013 so far, although most of that has come on his favorite surface.

The problem is that the Spanish star could end up being the No. 5 seed at this event, which means he could face one of the top players as early as the quarterfinals.

Finally, Andy Murray looks to come back strong after missing the French Open with a back injury. He recently won the Queen?s title and appears to be as strong of a contender as ever.

Any of these competitors and more are capable of winning it all, but the final matchup could depend on the draw as much as the play on the court.

Williams will be the clear favorite in this tournament as she returns to the spot where she began her renaissance.

After losing in the first round of the 2012 French Open, Williams got her act together and cruised to a win at Wimbledon. She then followed that up with a gold medal at the London Olympics, a win at the U.S. Open and a recent win at Roland Garros.

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The British women?s No1, Laura Robson, faces a daunting first-round match at Wimbledon after being drawn against the 10th seed, Maria Kirilenko.
The Russian was a quarter-finalist at Wimbledon last year and Robson, who went out in the first round last year, will have to be at her best against the 26-year-old. Robson, the world No37, has struggled in the buildup to this year?s tournament. The 19-year-old lost in the second round of the Aegon Classic in Birmingham last week and went out at of the Aegon International in Eastbourne on Tuesday.

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Subject to change
Time ?? ?Round ?? ?Net
Monday, June 24
7:00 AM-5:00 PM ?? ?Early round coverage ?? ?ESPN
Tuesday, June 25
7:00 AM-5:00 PM ?? ?Early round coverage ?? ?ESPN
Wednesday, June 26
7:00 AM-5:00 PM ?? ?Early round coverage ?? ?ESPN2
Thursday, June 27
7:00 AM-3:00 PM ?? ?Early round coverage ?? ?ESPN2
Friday, June 28
7:00 AM-5:00 PM ?? ?Early round coverage ?? ?ESPN
Saturday, June 29
7:00-8:00 AM ?? ??Breakfast at Wimbledon? ?? ?ESPN
8:00 AM-4:00 PM ?? ?Early round coverage ?? ?ESPN
Sunday, June 30
3:00-6:00 PM ?? ?Highlights of Week 1 ?? ?ABC
Monday, July 1
7:00 AM-5:00 PM ?? ?Round of 16 (Court 1 and outer courts) ?? ?ESPN2
8:00 AM-3:00 PM ?? ?Round of 16 (Centre Court) ?? ?ESPN
Tuesday, July 2
7:00 AM-4:00 PM ?? ?Women?s Quarterfinals (Court 1) ?? ?ESPN2
8:00 AM-1:00 PM ?? ?Women?s Quarterfinals (Centre Court) ?? ?ESPN
Wednesday, July 3
7:00 AM-4:00 PM ?? ?Men?s Quarterfinals (Court 1) ?? ?ESPN2
8:00 AM-3:00 PM ?? ?Men?s Quarterfinals (Centre Court) ?? ?ESPN
Thursday, July 4
7:00-8:00 AM ?? ??Breakfast at Wimbledon? ?? ?ESPN
8:00 AM-1:00 PM ?? ?Women?s Semifinals ?? ?ESPN
Friday, July 5
7:00-8:00 AM ?? ??Breakfast at Wimbledon? ?? ?ESPN
8:00 AM-2:00 PM ?? ?Men?s Semifinals ?? ?ESPN
Saturday, July 6
8:00-9:00 AM ?? ??Breakfast at Wimbledon? ?? ?ESPN
9:00 AM-3:00 PM ?? ?Women?s Final ?? ?ESPN
3:00-6:00 PM ?? ?Women?s Final (encore) ?? ?ABC
Sunday, July 7
8:00-9:00 AM ?? ??Breakfast at Wimbledon? ?? ?ESPN
9:00 AM-3:00 PM ?? ?Men?s Final ?? ?ESPN
3:00-6:00 PM ?? ?Men?s Final (encore) ?? ?ABC

Heather Watson, the British No2, also has an awkward draw after being pitted against the promising 18-year-old American, Madison Keys, who reached the third round of the Australian Open in January. However having reached the third round of Wimbledon last year, Watson will be confident of beating the world No53.
Johanna Konta, the world No137, will be up against it when she takes on the 16th seed, Jelena Jankovic, while Elena Baltacha plays the 31-year-old Italian, Flavia Pennetta and Anne Keothavong plays the 19-year-old Spaniard, Garbi?e Muguraza.

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Saturday, July 6, 2013

Microsoft dumps Xbox Live Arcade Points with next update

Video games

23 hours ago

Microsoft is abandoning its traditional e-commerce system for its popular online gaming and entertainment platform Xbox Live Arcade in time for the next schedule Xbox 360 dashboard update, the company revealed Friday.

Microsoft

Microsoft is abandoning its traditional e-commerce system for its popular online gaming and entertainment platform Xbox Live Arcade in time for the next schedule Xbox 360 dashboard update, the company revealed Friday.

After irritating gamers for nearly a decade with its requirement to buy digital goods with "Microsoft Points" rather than real-world currency, Microsoft's Xbox Live Arcade (XBLA) is laying its points system to rest both for the Xbox 360 and the upcoming Xbox One console.

Previously, gamers wanting to purchase anything on XBLA had to first purchase a batch of Microsoft points ? say, 1,600 points for $19.99 ? with which they could then actually buy a game. This system invariably led to an imperfect overlap between the amount of points needed to buy something and the amount sitting around in a given XBLA account afterwards, leading to complaints that the service was generally inefficient and unnecessarily costly.

Larry Hryb, Xbox Live's director of programming who's better known by his online moniker "Major Nelson," announced the shift on Friday in a post on his blog about the upcoming open beta testing period scheduled for the next Xbox 360 dashboard update.

"It [the 2013 Xbox Live Update for Xbox 360 Public Beta] will include updates to improve overall performance and the ability to conduct transactions with local currency, as Microsoft Points will be retired later this year," Hryb wrote.

Hryb didn't say when the final update would be released to the general gaming public. Microsoft first announced that it was retiring its points system for XBLA e-commerce during its press conference at the Electronic Entertainment Expo (E3) in Los Angeles.

Hryb also didn't clarify how, exactly, Microsoft is planning to deal with any leftover Microsoft points after the e-commerce solution is officially abandoned for Xbox Live. We've reached to Microsoft for comment and will update this story as more information becomes available.

Yannick LeJacq is a contributing writer for NBC News who has also covered technology and games for Kill Screen, The Wall Street Journal and The Atlantic. You can follow him on Twitter at @YannickLeJacq and reach him by email at: ylejacq@gmail.com.

Source: http://feeds.nbcnews.com/c/35002/f/663301/s/2e4312f0/l/0L0Snbcnews0N0Ctechnology0Cmicrosoft0Edumps0Exbox0Elive0Earcade0Epoints0Enext0Eupdate0E6C10A547238/story01.htm

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Wes Brown: University of Maryland student arrested

A University of Maryland running back was arrested and charged with second degree assault, stealing and the illegal use of a wiretap, according to SB Nation.

Police arrested sophomore Wes Brown on Wednesday and the school on Friday announced he is suspended.

"We are extremely concerned that one of our student-athletes, Wes Brown, was arrested Wednesday evening,? the school said in a statement. ?This is a matter that we take very seriously. We have been in contact with the local authorities and will continue to cooperate throughout the entire process.?

SB Nation reports that police were searching for Brown and the UMD student allegedly assaulted an officer and then fled. The wiretapping charge stems from Brown allegedly videotaping an officer with his cell phone without the officer knowing.

READ MORE at Testudo Times.

Source: http://www.wjla.com/articles/2013/07/wes-brown-university-of-maryland-student-arrested-91024.html

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BlackBerry signs up for Sony?s Crackle

Kurt Cobain on Crackle x405

Friday, July 5th, 2013. Posted in News

Sony Pictures TV said that its Crackle online video entertainment network will now be available on Blackberry 10 smartphones.

You need to be logged in to see this part of the post. [ Register ]

Source: http://www.cueentertainment.com/blackberry-signs-up-for-sonys-crackle/

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Friday, July 5, 2013

NBA High-5: Robin Lopez not a home run for Blazers, but he should help them

The five most interesting stories, rumors and notes in the NBA:

1. Middle man: I guess no one in the NBA celebrates the 4th of July? You could practically hear this exchange:

Neil, your hot dog's getting cold!

I'll be right there!

For Trail Blazers GM Neil Olshey and executives from the Pelicans and Kings, there was work to be completed Thursday. The result was an Independence Day deal that sent Tyreke Evans to the Pelicans, Greivis Vasquez to the Kings and brings Robin Lopez to Portland.

The Blazers sent the rights to second-round draft pick Jeff Withey to New Orleans and two future second-round draft picks to Sacramento.

Apparently Olshey wasn't the only one taking time away from July 4th celebrations to ponder Blazers doings as the story on the deal by The Oregonian's Joe Freeman and a column on it by John Canzano both drew more than 200 comments.

The reactions have been quite a mixed bag, some praising Olshey for, as Canzano wrote, making a deal without giving up all that much, others disappointed that the Blazers didn't get a different center, many mentioning the Rockets' Omer Asik.

Asik was never going to be easy to get. The Rockets' are laser-focused on signing Dwight Howard, and they've either cleared enough cap space, or are a few waives away from doing so. However, the Rockets also have to leave open the possibility of doing a sign-and-trade with the Lakers, and Asik could be a usable piece that Houston needs to hang onto to keep their options open.

Instead of waiting that out, with no real guarantee, the Blazers got Lopez while that door was still open.

Is this a home run? No, but the Blazers did a get a center who could help them. Lopez started all 82 games and averaged 11.3 points, 5.6 rebounds and 1.6 blocks in 26 minutes a game, all career-highs. It's hard to really flesh out his numbers, though, as New Orleans played at snail's pace, ranking No. 30 in the league in pace.

Lopez is a 7-foot center with five years of NBA experience who's played in two completely different styles with the Suns and Hornets.

Also, Lopez brings an attractive contract that will pay him $10.5 million over the next two seasons. The contract will become fully guaranteed on July 15 (if the Blazers waive him before before then, they would only owe him $500,000, but that's surely not going to happen).

ESPN's Marc Stein reported that Lopez has a trade kicker and will be owed $1,568,999. Stein writes that the Blazers will have to pay the bonus, but by my reading of the new CBA, because Lopez signed the deal last summer, after the new CBA was in effect, New Orleans will have to pay it.

However, in one of those CBA quirks, it appears the kicker would have to be added to Portland's salary cap, divided over two seasons, which would shave slightly more off? its remain room.

The Blazers, by the way, have called a Monday news conference to introduce CJ McCollum, their first-round draft pick. Some of us found it odd that they did not say that second-round picks Allen Crabbe and Withey would also be introduced, and I guess we see why with Withey. Who know what that means for Crabbe.

2. Go tell it to the mountain: Dwight Howard, all his meetings with suitors done, is holed up in Aspen, Colo., trying to make the decision on which team he will play for next season and beyond.

There's been media speculation that Howard could make a decision today, but that might just be guys hoping for this to not drag into the weekend. It's unclear if any of the teams could be considered a front-runner.

The Lakers seem to have fallen out of favor, and some of the blame might go to Kobe Bryant. During the Lakers' pitch, Bryant told Howard that he would teach the center how to be a champion, that "you have to learn how it's done," Yahoo's Adrian Wojnarowski reports. That message could have hurt the Lakers' chances of getting Howard back, ESPN's Chris Broussard reports.

Golden State seems to be emerging as a legitimate candidate, a surprise considering they don't have the cap space to sign Howard. But ESPN reports that the Warriors have been furiously trying to clear money by trading Andrew Bogut ($14 million due next season), Richard Jefferson ($11 million) and Andris Biedrins ($9 million). Utah is apparently interested in Bogut.

[UPDATE, 1 p.m.: Yahoo's Adrian Wojnarowski reports that the Warriors have agreed to a deal that would send Jefferson and Biedrins to Utah. Instead of Howard, however, Golden State used its space to agree to a four-year, $48 million deal with Andre Iguodala. If the Warriors are to get Howard, the only way now would be to entice the Lakers into a sign-and-trade.]

Golden State could also try to get a sign-and-trade done with the Lakers, who could be forced to look at that scenario.

The one real unknown in the Howard sweepstakes has been Dallas. ESPNDallas.com's Tim MacMahon reports that Mavericks owner Mark Cuban has kept a tight lid on leaks, which explains why there have been no anonymously-sourced reports about how Dallas' meeting with Howard went. "We don't test the waters in the media," Cuban tells MacMahon. "We don't troll on Twitter."

Rockets GM Daryl Morey is active on Twitter, and he sent out out a link to a YouTube plea from "Big Bang Theory" actor Jim Parsons, a big Rockets fan:

3. The big surprise: In this day and age, it's hard to pull off a genuine surprise in the NBA, but the Celtics sure did by hiring Brad Stevens as coach.

Stevens' entire head coaching resume is 13 years at Butler, a smallish college (enrollment 4,500) in Indiana that has had great success under him, getting to the NCAA championship game in 2010 and '11.

As the Boston Globe's Christoper Gasper writes, plenty of college coaches have made the move to the NBA and flopped, including Rick Pitino with the Celtics. Stevens has never played or coached in the NBA, so there is a steep, steep learning curve for him.

With Doc Rivers off to the Clippers, Boston's president of basketball operations Danny Ainge went way out on a limb, but it's apparently not a rash decision. Ainge has had Stevens on his radar for years, the Globe's Baxter Holmes reports.

The big question for Stevens is, can he get the best out of Rajon Rondo, the Celtics' mercurial point guard. Stevens, 36, said at his introductory news conference this morning that he had already spoken to Rondo and added, "There is no bigger fan of Rajon Rondo than me."

4. The big signing: One big free-agent center did make a decision this week as Al Jefferson agreed to a three-year, $40.5 million deal with Charlotte. The deal includes a third-year player option.

This is unprecedented stuff for Bobcats, with Charlotte Observer's Rick Bonnell calling it the "boldest and most expensive free-agent acquisition in the franchise?s decadelong history."

ESPN's Stein reports that the Bobcats will us the amnesty clause on forward Tyrus Thomas, who has two years and $18 million left on his contract. Thomas, of course, was originally drafted by the Blazers in 2006, then immediately traded to Chicago as part of a package that brought LaMarcus Aldridge to Portland. Thomas has never come close to fulfilling his potential, but for whatever reason, Charlotte gave him a five-year, $40 million extension in 2010.

The Observer's Tom Sorenson, who had written that he hoped the Bobcats would not sign Jefferson, writes that the Bobcats could be good in two years.

Maybe so. Jefferson is a rarity in the NBA these days -- an offensive center who scores in the post. The Bobcats drafted Cody Zeller, who could be a stretch-four complement to Jefferson's post game, so maybe Jefferson can put up some big numbers. He is not, however, a very good defender.

5. Ex-Blazers check: The Knicks have made a habit of stocking up on players who once played for the Blazers (last season, they had Raymond Felton, Kurt Thomas, Marcus Camby and Rasheed Wallace), and they could add another.

The New York Post reports that the Knicks are considering signing Sebastian Telfair as a third point guard behind Felton and Pablo Prigioni.

Since being drafted out of high school by Portland in 2004, Telfair has played on seven NBA teams, including Phoenix and Toronto last season. Joining the Knicks would surely be special for the Brooklyn native, though.

Another former Blazers point guard, Nolan Smith, will play for the Celtics in the Orlando Pro Summer League. Dukereport.com's Chris Summerville notes that Smith was on the Duke team that beat Steven's Butler squad in the 2010 NCAA final.

The Orlando summer league starts play Sunday, and there will be few other familiar faces. Former Blazers point guard Jonny Flynn will on Indiana's squad. Former Oregon standout Arsalan Kazemi will play for the 76ers, who drafted him in the second round.

Another former Duck, Michael Dunigan, will play for Miami. He was in training camp with Memphis last season, but was waived, then played in Australia and the Philippines.

The Orlando league is small, with 10 franchises sending 12 teams, and is not open to the public. The bigger Las Vegas Summer League -- with 22 teams, including Portland -- starts a week from today.

Rosters for Vegas are slowly trickling out. Golden State's has a familiar name -- Craig "Rhino" Smith, who played for the Blazers in 2011-12. Smith, 29, played in Israel and China after leaving the Blazers and is apparently willing to play with young guys for a chance to get back in the league.

Surely there's enough whimsy in the league that there's room for a burly, 6-7 power forward who for a while spoke entirely in the third person, using his nickname.

-- Mike Tokito

Source: http://www.oregonlive.com/nba/index.ssf/2013/07/nba_high-5_388.html

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Stocks jump after strong June jobs report

Economy

9 hours ago

A man walks past a stock quotation board displaying Japan's Nikkei share average outside a brokerage in Tokyo July 5, 2013.

Toru Hanai / Reuters

A man walks past a stock quotation board displaying Japan's Nikkei share average outside a brokerage in Tokyo July 5, 2013.

The stock market appeared conflicted Friday as investors weighed a better than expected June jobs report against worries about the end of the Federal Reserve's bond buying policy.

Stocks ended higher at the closing bell Friday: The Dow closed at 15,135, up nearly 1 percent over the previous trading day, propelled by gains in AmericanExpress and banking giant JPMorgan. The S&P 500 and Nasdaq made similar gains.

The jobs report means the economy is improving and is on track to at least pick up a little bit of momentum, Robert Pavlik, Banyan Partners' chief market strategist, told CNBC.

"I think the market is going to continue to move higher even as we approach the July meetings," he said. But as it gets closer to September "the possibility that market gets a little bit worried about the move up in Treasury yields comes back into play."

The U.S. economy created 195,000 new non-farm payroll jobs in June, the Labor Department reported, after an upwardly revised 195,000 jobs were created in May. The unemployment rate was unchanged at 7.6 percent as more people entered the labor market.

Markets had been awaiting the jobs report for clues as to when the Federal Reserve would begin tapering, or reducing its bond purchases. The Fed has said it expects to end its $85 billion monthly asset purchases when the unemployment rate drops to around 7 percent.

Jan Hatzius, Goldman Sachs chief economist, also is now calling for that to occur in September. "It's not a done deal. It could still be December," he told CNBC. "But when I take everything together?what they've said, what you've seen in the numbers? September is more likely."

On Friday, small-cap stocks and regional banks were among the market leaders.

"These are the sectors you want to see leadership from," Ryan Detrick, senior technical strategist at Schaeffer's Investment Research said, since they are closely tied to the U.S. domestic economy.

Home builders were among the weakest industry groups as investors fret about what higher interest rates will mean for the housing recovery.

The dollar jumped to a three-year high and 10-year Treasury yields pushed above 2.70 percent given the stronger data and growing anticipation of Fed tapering. Gold tumbled 3 percent.

(Read More: Why Higher US Yields Should Cheer Investors)

While the U.S. central bank may be closer to pulling back on the bond purchases, yesterday, both the European Central Bank and the Bank of England offered forward guidance on policy for the first time, and said record-low interest rates would be maintained for a prolonged period.

(Read More:July 4: Independence Day for Europe's Central Banks?)

Among stock movers, Dell was sharply lower on reports Michael Dell and Silver Lake will not raise their $24.4 billion buyout bid.

?Follow CNBC's Justin Menza on Twitter @JustinMenza.

More business news:

Follow NBCNews.com business onTwitter and Facebook

Source: http://feeds.nbcnews.com/c/35002/f/663286/s/2e435b79/l/0L0Snbcnews0N0Cbusiness0Cstocks0Ejump0Eafter0Estrong0Ejune0Ejobs0Ereport0E6C10A548482/story01.htm

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Contemporary One-Level Family House By Stephenson ISA Studio

A relaxing ambience, lush vegetation and a bright and breezy house ? meet House 780, a project designed by Stephenson ISA Studio, in?Manchester, England. The client?s former house had minimal views over the surroundings. With a different orientation, the house could had captured the essence of the landscape. So, the challenge was to modify the house?s orientation, in order to take advantage of the site?s topography and expose stunning views across the surroundings of?Halebarns, Manchester. ?The form of the building is formed by two blocks, set at different levels, one of which incorporates a double height living space that takes advantage of the sites topography and provides views across the surrounding landscape via full height 5m glazing to the South elevation.?
?The house can be accessed via two bridges: a vehicle bridge and ?a pedestrian one. The pedestrian bridge carries your steps directly onto the mezzanine floor. Once inside, you notice the bright and warm living environment. ?The living room is flooded by light, due to the glass panels (floor-to-ceiling windows) that replace the regular walls. Whenever you feel like enjoying moments of tranquility,?you can simply go for a walk around or sit in the garden, exploring from there, the wonders of the surrounding landscape.

Source: http://freshome.com/2013/07/05/contemporary-one-storey-family-house-by-stephenson-isa-studio/

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Thursday, July 4, 2013

Gabrielle Union: I Lost Out on Scandal to Kerry Washington!

Source: http://www.thehollywoodgossip.com/2013/07/gabrielle-union-i-lost-out-on-scandal-to-kerry-washington/

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Founder Stories: Swell's Ram Ramkumar On Transitioning From CTO To CEO

Screen Shot 2013-07-03 at 12.22.43 PMFor today's Founder Stories, I met with Ram Ramkumar, co-founder and new CEO of Concept.io, which last week launched Swell, an adaptive mobile app that streams audio news content. Ram explains how, as CEO, he has to focus on usability and design, which is in contrast to his experience running a technical team at Snaptell.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4i5hYlPqxrM/

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Celebrate the Fourth With a BBQ and an Inaccurate Anatomy Lesson

Celebrate the Fourth With a BBQ and an Inaccurate Anatomy Lesson

What would a Fourth of July be without the grillmaster donning some manner of wacky apron while they serve up burgers and hot dogs? That's right, just another summer day. So do things right this year, and treat your guests to a complimentary but dangerously inaccurate anatomy lesson with this official $23 Operation apron.

It's basically just a version of the board game you can wear, with your head filling in for the poor guy who's usually under the knife. It means the glowing red nose that makes the game particularly fun is gone, but feel free to jam a tomato on there after a beer or ten.

. [I Want One Of Those via GeekAlerts]

Source: http://gizmodo.com/celebrate-the-fourth-with-a-bbq-and-an-inaccurate-anato-660778579

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Wednesday, July 3, 2013

Are Rihanna and Jennifer Lawrence New BFFs?

The stars run into each other in Paris! Check out other cute and candid moments from the stars.

Source: http://www.ivillage.com/celebrity-twitter-pictures/1-b-229669?dst=iv%3AiVillage%3Acelebrity-twitter-pictures-229669

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Candy Crush Saga: Another 10 killer help, hints, and extra lives!

Definitive Candy Crush guide: How to play for eternity, reshuffle your start, and crush all the candy you can!

If you enjoyed our you'll love our second set of top ten winners! Here's where we get into reshuffling your start, crushing even more candy, and... playing for eternity thanks to Facebook!

  1. Reshuffle your candies without losing lives Sometimes just by looking at a new level you know if you'll be in for an easy or a hard time. Luckily, there's a way to change that, and reshuffle a challenging level, without using up any of your lives. On your mobile device, open the level and then press the exit button before you make any moves. When you come back, the candy will be reshuffled and in new, hopefully easier to handle positions. You can do this as many times as you want and no lives will be lost. This trick does not work on the time challenges as the game has already started as the time counts down.

Reshuffle your candies without losing lives

  1. Infinite lives on Facebook On your web browser you can keep multiple tabs open and on Candy Crush at the same time. This means that for those really hard levels you will never have to wait for lives to refresh as on each open version of Candy Crush you have 5 lives ready. When you do pass a level you will have to refresh each webpage but this is exceptionally helpful for those levels which take a lot of lives to pass. Below you can see I have 5 tabs open to Candy Crush and each with 5 lives. Yes, I stole Rene's facebook account to play Candy Crush on it.

  1. Time Challenge add time The trick to passing timed levels is getting as many +5 candies as possible to add more time to clock. Understanding why the +5 candies drop really helps as they do not just drop randomly. The +5's drop every time you make a move which causes a cascade of 4 or more combos. Then make sure you crush that +5 to add it to your timer. You increase your chances of creating a cascade by crushing candies at the bottom of the board as there are more candies above you to make a second, third and then fourth set. Try this on level 252 and you can play until you get bored of the level, I stopped when I hit 1,000,000 points and still had the full 30 seconds on the clock.

  1. Use striped candies strategically Do not waste your striped candies as soon as you get them. Try to plan out where they would be most beneficial and use them to reach those hard to get candies. There are some levels that this skill is essential for passing the level.

Use striped candies strategically

  1. Save your fish for last Fish candies will zone in on any remaining jellies. Save them for last so you can have them get those hard to reach jellies. They will also get rid of jellies which are under frosting blocks without needing to get rid of the frosting making passing levels even faster.

Save your fish for last

  1. Finish with extra moves left If you complete a level with extra moves left over they will transfer into more points as a school of jelly fish or striped candy will clear parts of the board. This does not guarantee that you will garner more points but usually it is a safe bet in order to hit those high scores

Finish with extra moves left

  1. Pink bow If you have a level with a pink bow on it, then one of your Facebook friends have given you a gift of 3 extra moves. To use this on mobile, just play the level and the three extra moves are added automatically. If you are playing on the web on Facebook you can see the number of +3 moves you were given in the starting screen. You just click on the +3 moves in the starting screen to activate it.

Pink bow

  1. Gifts from friends You only have a maximum of 5 lives (or sometimes 6) so dont accept lives from your friends until you can use them. If you accept lives when you are already maxed out the lives are wasted. I use the X to close the screen and wait until I'm under 5 lives remaining to click accept. Also know that the level you happen to be on when you accept a +3 moves will be the level that gift must be used on. So I only accept a +3 moves gift on the levels I am really struggling with.

Gifts from friends

  1. Battle Plan You want to eliminate the most dangerous candies first. Usually that would mean clearing the bombs then chocolate and finally any locked candies.

Battle Plan

  1. Dealing with ingredients You do not want to start a level with ingredients on the far right or left of the board. Along the sides of the screen, you have many fewer options to create a set of three or more similar candies. You can restart the level if you notice this before you have moved (see tip 1). You can also try to move the ingredients closer to the middle by crushing candies. Unless forced never move an ingredient to a square with no exit underneath it or to the side of the screen. The exits look like small green circles with white arrows inside them.

Dealing with ingredients

I hope you have enjoyed my new tips and cheats for Candy Crush Saga. I'd love to hear how they work for you in the comments, and if you've come across any other great Candy Crush tips, tricks, or cheats, for the sake of my sanity, let me know! Tweet if you have any questions, new tips, or just need additional Candy Crush addiction support @Georgia_Prime!

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/4ITVEcDT5sw/story01.htm

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Airliner near-misses prompt call for changes to 'go-around' rules

By Tom Costello and Tracy Jarrett, NBC News

Five recent near-misses involving commercial airliners has prompted the National Transportation Safety Board to make recommendations for new rules to avoid such close calls -- even as the agency investigates a new incident over Michigan.

The recommendations to the Federal Aviation Administration refer to aircraft arriving at or departing crowded airports and would modify rules for air traffic controllers to ensure the safe separation of planes during "go-around" maneuvers.

The go-around - an aborted landing attempt by an airplane on final approach - can be initiated at the direction of air traffic control or by the flight crew when a determination is made that circumstances are unfavorable for a safe landing.

The safety hazard identified in the five incidents -- two of which happened on the same day last July -- each occurred when an airplane on approach aborted the landing attempt and initiated a go-around maneuver, which put the go-around airplane on a flight path that intersected with that of another airplane that was either departing or arriving on another runway of the same airport.

Although current FAA procedures have specific requirements for ensuring the separation between two airplanes that are departing from different runways but that have intersecting flight paths, they do not prohibit controllers from clearing an airplane to land at a time when it would create a potential collision hazard with another aircraft if the pilots of the landing airplane perform a go-around.?

In such situations, a flight crew performing a go-around may be put into the position of having to execute evasive maneuvers at low altitude and high closing speeds with little time to avoid a mid-air collision.

The NTSB has determined that existing FAA separation standards and operating procedures are inadequate and need to be revised to ensure the safe separation between aircraft near the airport environment.

The NTSB cannot force the FAA to implement any recommendations, but according to a statement from the FAA, ?the FAA's Air Traffic Organization thoroughly investigated the incidents and took aggressive steps to address the causes. The FAA takes NTSB recommendations very seriously and will respond to the board in a timely manner.?

Meanwhile, the NTSB is investigating a close call of a Spirit Airlines flight Sunday that led the Airbus to dive 1,600 feet to avoid a skydiving jump plane.?

The incident took place about 40 miles outside Detroit Metropolitan Wayne County Airport and would not have been affected by the proposed rule modifications.

Source: http://feeds.nbcnews.com/c/35002/f/663306/s/2e1a96dd/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A70C0A20C19250A8850Eairliner0Enear0Emisses0Eprompt0Ecall0Efor0Echanges0Eto0Ego0Earound0Erules0Dlite/story01.htm

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It's about time: Disrupted internal clocks play role in disease

July 1, 2013 ? Thirty percent of severe alcoholics develop liver disease, but scientists have not been able to explain why only a subset is at risk. A research team from Northwestern University and Rush University Medical Center now has a possible explanation: disrupted sleep and circadian rhythms can push those vulnerable over the edge to disease.

The team studied mice that essentially were experiencing what shift workers or people with jet lag suffer: their internal clocks were out of sync with the natural light-dark cycle. Another group of mice had circadian disruption due to a faulty gene. Both groups were fed a diet without alcohol and next with alcohol, and the team then examined the physiological effects.

The researchers found the combination of circadian rhythm disruption and alcohol is a destructive double hit that can lead to alcoholic liver disease.

The study was published last month by the journal PLOS ONE.

"Circadian disruption appears to be a previously unrecognized risk factor underlying the susceptibility to or development of alcoholic liver disease," said Fred W. Turek, the Charles E. and Emma H. Morrison Professor of Biology at Northwestern's Weinberg College of Arts and Sciences and one of the senior authors of the paper.

"What we and many other investigators are doing is bringing time to medicine for the diagnosis and treatment of disease," Turek said. "We call it circadian medicine, and it will be transformative. Medicine will change a great deal, similar to the way physics changed when Einstein brought time to physics."

A number of years ago, Ali Keshavarzian, M.D., a gastroenterologist at Rush University Medical Center who has worked with and studied patients with gastrointestinal and liver diseases, had a hunch disrupted circadian rhythms could be a contributing factor to the disease.

Keshavarzian had noticed that some patients with inflammatory bowel disease (inflammation in the intestine and/or colon) had flare-ups of symptoms when working nights, but they could control the disease when working the day shift. He sought out Turek, director of Northwestern's Center for Sleep and Circadian Biology, to help investigate the relationship between circadian rhythms and the disease.

The two investigators and their groups first studied the effect of circadian rhythm disruption in an animal model of colitis and noted that disruption of sleep and circadian rhythms (caused by modeling shift work and chronic jet lag in the animals) caused more severe colitis in mice.

Keshavarzian has been studying the effect of "gut leakiness" (the intestinal lining becomes weak and causes dangerous endotoxins to get into the blood stream) to bacterial products in gastrointestinal diseases for two decades. Because the mouse model of colitis is associated with leaky gut, he proposed that disruption of circadian rhythms from shift work could make the intestine more susceptible to leakiness. He wanted to test its effect in an animal model of alcoholic liver disease -- where a subset of alcoholics develop gut leakiness and liver disease -- in order to find out whether shift work is the susceptibility factor that promotes liver injury.

"Non-pathogen-mediated chronic inflammation is a major cause of many chronic diseases common in Western societies and developing countries that have adopted a Western lifestyle," said Keshavarzian, one of the senior authors of the paper. He is director of the Division of Digestive Diseases and the Josephine M. Dyrenforth Chair of Gastroenterology.

Crohn's and ulcerative colitis, Parkinson's disease, diabetes, multiple sclerosis, autoimmune disease and cardiovascular disease are examples of these diseases, to name just a few.

"Recent studies have shown that intestinal bacteria are the primary trigger for this inflammation, and gut leakiness is one of the major causes," Keshavarzian said. "The factor leading to gut leakiness is not known, however. Our study suggests that disruption of circadian rhythms and sleep, which is part of life in industrial societies, can promote it and explain the susceptibility."

In the study, the Northwestern and Rush researchers used two independent approaches, studying both genetic and environmental animal models. The circadian rhythms of one group of mice were disrupted genetically: Each animal had a mutant CLOCK gene, which regulates circadian rhythms. The second group's circadian rhythms were disrupted environmentally: The animals' light-dark cycle was changed periodically, leading to a state similar to chronic jet lag.

Mice in both groups, prior to ingesting alcohol, showed an increase in gut leakiness.

Next, both groups of mice were fed alcohol. After only one week, animals in both groups showed a significant additional increase in gut leakiness, compared to control mice on an alcohol-free diet. At the end of the three-month study, mice in both groups were in the early stages of alcoholic liver disease.

"We have clearly shown that circadian rhythm disruption can trigger gut leakiness, which drives the more severe pathology in the liver," said Keith Summa, a co-first author of the study and an M.D./Ph.D. candidate working in Turek's lab.

"For humans, circadian rhythm disruption typically is environmental, not genetic, so individuals have some control over the behaviors that cause trouble, be it a poor sleep schedule, shift work or exposure to light at night," he said.

Sleep and circadian rhythms are an integral part of biology and should be part of the discussion between medical doctors and their patients, the researchers believe.

"We want to personalize medicine from a time perspective," Turek said. "Our bodies are organized temporally on a 24-hour basis, and this needs to be brought into the equation for understanding health and disease."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/RduZVm6IweM/130701163944.htm

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